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Determination of the particle size and particle shape of pharmaceutical granules with the CAMSIZER®
PDF-Download:Pharmaceutical granules are, from a technical point of view, agglomerates that usually consist of a mixture of a medicinal agent and various excipients.
The granules can be prepared by different methods. One of these is dry granulation, a simple and rapid method. Mixtures of powders containing the active substance are compressed with tablet presses or roller compactors to form larger units and are then reduced to the required granule size by using mills or sieve granulators. The different granule sizes produced in this way naturally have irregular shapes. Granulation is often used for obtaining a particular mixture quality as well as for improving the flow and compression properties of the powder mixture. A more recent field of application is the use of such dry granules as an independent form of drug, which release the active substances as uniformly as possible throughout a certain period (8 – 12 hours). These so-called retard drug forms benefit the patient by having longer administration intervals and accordingly a reduced administration frequency when compared with conventional drug forms.
